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**Organisms may persist in the renal tubules, uterus, eye or meninges
**Organisms may persist in the renal tubules, uterus, eye or meninges
**Evade phagocytosis possibly via macrophage apoptosis
**Evade phagocytosis possibly via macrophage apoptosis
**Damage red blood cell membranes and endothelial and liver cells, leading to haemolytic anaemia, jaundice, [[General Pathology - Pigmentation and Calcification#Haemoglobin|haemoglobin pigmentation]], haemoglobinuria and haemorrhage in acute leptospirosis
**Damage red blood cell membranes and endothelial and liver cells, leading to haemolytic anaemia, jaundice, [[Pigmentation and Calcification - Pathology#Haemoglobin|haemoglobin pigmentation]], haemoglobinuria and haemorrhage in acute leptospirosis
*Diagnosis
*Diagnosis
***The host-adapted serovar ''canicolar'' causes acute renal failure in puppies; a chronic uraemic syndrome may follow
***The host-adapted serovar ''canicolar'' causes acute renal failure in puppies; a chronic uraemic syndrome may follow
***Incidental infections with serovar ''icterohaemorrhagica'' or ''copenhagenii'' cause renal failure
***Incidental infections with serovar ''icterohaemorrhagica'' or ''copenhagenii'' cause renal failure
***''L. icterohaemorrhagiae'' may cause [[General Pathology - Pigmentation and Calcification#Hepatic (Toxic) Icterus|hepatic jaundice]]
***''L. icterohaemorrhagiae'' may cause [[Pigmentation and Calcification - Pathology#Hepatic (Toxic) Icterus|hepatic jaundice]]
***Serovar ''bratislava'' causes abortion and infertility in dogs, which may be the maintenance host
***Serovar ''bratislava'' causes abortion and infertility in dogs, which may be the maintenance host
***Infections uncommon in cats
***Infections uncommon in cats