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, 21:07, 13 August 2009
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|linkpage =General Pathology
|linktext =General Pathology
|maplink = General Pathology (Content Map)
|pagetype =Pathology
|sublink1=Inflammation - Pathology
|subtext1=INFLAMMATION
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==Introduction==
* Inflammation is the process by which cells and exudate accumulate in irritated tissues and usually tend to protect them from further injury.
==Cardinal Signs==
* The classical gross signs of inflammation have been recognised since the time of Celsus (25BC-AD50).
** These are known as the cardinal signs of inflammation.
# '''Reddening'''
#* Caused by increased blood flow (hyperaemia) to the area, due to dilation of previously inconspicuous capillaries..
# '''Swelling'''
#* The inflamed area appears swollen due to exudation of fluid from the dilated blood vessels into the inflamed tissue.
# '''Heat'''
#* There is increased heat in the affected tissue due to increased blood flow.
#* The temperature of the inflamed portion approximates to internal body temperature.
# '''Pain'''
#* Chemical mediators of pain are release by damaged tissue. in the affected tissue caused by #* Inflammatory exudate puts local pressure on nerve endings.
# '''Loss of function'''
#* The pain and damage to the tissue result in a reluctance to use the inflamed portion.
==Causes==
* Inflammation has many causes:
** Microorganisms and helminths (parasites).
** Trauma
** Mechanical, thermal, and chemical agents.
** Some immune reactions
*** Hypersensitivity/ allergy.
** Malignant neoplasms.