Changes

*Often needs two or more doses  

*Often needs two or more doses  

**The first dose initiates the '''priming''' reaction where [[Immunoglobulins - WikiBlood|antibody]] production ceases after a few weeks, but the second and subsequent doses creates [[B cell differentiation - WikiBlood#Memory cells|memory cells]] which remain in the circulation for a much longer period of time

**The first dose initiates the '''priming''' reaction where [[Immunoglobulins - WikiBlood|antibody]] production ceases after a few weeks, but the second and subsequent doses create [[B cell differentiation - WikiBlood#Memory cells|memory cells]] which remain in the circulation for a much longer period of time

**For further information on the T cell independent and dependent responses click [[B cell differentiation - WikiBlood#T-Cell Dependent and Independent Responses|here]]

**For further information on the T cell independent and dependent responses click [[B cell differentiation - WikiBlood#T-Cell Dependent and Independent Responses|here]]