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→Spectrum of Activity
* Works well against Mycoplasmas and Rickettsia.
* Works well against Mycoplasmas and Rickettsia.
* Poor activity against obligate anaerobes.
* Poor activity against obligate anaerobes.
* Their activity is very pH dependent wit their activity increasing above pH 7.4 and decreasing below pH 7.0.
* Their activity is very pH dependent with their activity increasing above pH 7.4 and decreasing below pH 7.0.
It should be noted that they are active at very low concentrations, they don't kill protective enterococci and anaerobes, and they will inhibit aminoglycoside and beta-lactam resistant bacteria.
It should be noted that they are active at very low concentrations, they don't kill protective enterococci and anaerobes, and they will inhibit aminoglycoside and beta-lactam resistant bacteria.
==Pharmacokinetic Considerations==
==Pharmacokinetic Considerations==