Changes

* '''Blood vessels''', to decrease vasodilation and fluid exudation.

* '''Blood vessels''', to decrease vasodilation and fluid exudation.

* '''Inflammatory mediators''', by:

* '''Inflammatory mediators''', by:

** Inhibiting cyclo-oygenase, leading to a decrease in prostanoid levels.

** Inhibiting cyclo-oxygenase, leading to a decrease in prostanoid levels.

** Inhibiting phosphlipase-A2, reducing conversion of phospholipid to arachidonate and therfore mediator production.

** Inhibiting phosphlipase-A2, reducing conversion of phospholipid to arachidonate and therefore mediator production.

** Decreasing generation of inflammatory cytokines.

** Decreasing generation of inflammatory cytokines.

** Decreasing histamine release.

** Decreasing histamine release.