Changes

====Histological Appearance of Fatty Change====

====Histological Appearance of Fatty Change====

* The fat appears either as globules or is contained in varying sizes of vacuoles in the cytoplasm.

* The fat either appears as globules or is contained in varying sizes of vacuoles in the cytoplasm.

** In the heart, it appears as tiny groups of vacuoles dispersed along the myofibrils throughout the whole cell.  

** In the heart, fat appears as groups of tiny vacuoles dispersed along the myofibrils.  

** In the liver and kidney, these vacuoles tend to, but not always, coalesce (come together;

** In the liver and kidney, vacuoles tend to coalesce to form larger ones.

fuse with one another ) to form larger ones, and you may see one or more large globules filling the cytoplasm with displacement of the nucleus to the periphery of the cell.  

*** One or more large globules may fill the cytoplasm.

The nucleus remains normal unless the degree of fatty change becomes incompatible with the continued existence of the cell.

**** The nucleus is displaced to the periphery of the cell.  

* The nucleus remains normal.

** Nuclear changes are only seen if the degree of fatty change becomes incompatible with the continued existence of the cell.

To decide whether or not a vacuole in the cytoplasm of a hepatocyte is fat ( because there are

To decide whether or not a vacuole in the cytoplasm of a hepatocyte is fat ( because there are

two further conditions which may produce vacuoles in hepatocytes, namely the vacuolar

two further conditions which may produce vacuoles in hepatocytes, namely the vacuolar