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| | radiation but the availably of teletherapy and interstitial brachytherapy is | | radiation but the availably of teletherapy and interstitial brachytherapy is |
| | very limited. The expense and practicality are severely limiting factors. | | very limited. The expense and practicality are severely limiting factors. |
| | + | |
| | + | ==Cell Transformation== |
| | + | |
| | + | [[Image:Wound sarcoid.jpg|left|thumb|250px|<small><center>Sarcoid (Image courtesy of [http://drupal.thedonkeysanctuary.org.uk The Donkey Sanctuary])</center></small>]] |
| | + | [[Image:Sarcoid removed wound.jpg|right|thumb|250px|<small><center>Wound following removal of sarcoid (Image courtesy of [http://drupal.thedonkeysanctuary.org.uk The Donkey Sanctuary])</center></small>]] |
| | + | [[Image:Healing of sarcoid wound.jpg|right|thumb|250px|<small><center>Healing of wound (Image courtesy of [http://drupal.thedonkeysanctuary.org.uk The Donkey Sanctuary])</center></small>]] |
| | + | [[Sarcoid - Donkey|Sarcoid]] transformation at wound sites is a very common (and increasingly important) reason |
| | + | for wound healing failure. Sarcoid fibroblasts are a strong inhibitor of wound healing and the extent |
| | + | of the sarcoid within the wound/granulation tissue needs not to be high for inhibition to occur. The |
| | + | extent of the transformation is sometimes very limited but the effects remain profound. Healing |
| | + | is inhibited until all tumour cells are removed. |
| | + | |
| | + | Confirmation of the problem is not always easy. Multiple biopsies from different parts of the tissue should be taken to ensure the maximum chance of finding it. |
| | + | |
| | + | Special precautions such as early dressing application and particularly |
| | + | control of fly contact should be taken to protect wounds on donkeys that |
| | + | already have sarcoids at other sites. Wounds that involve sarcoid tissue |
| | + | are extremely dangerous because they are very difficult and sometimes |
| | + | impossible to treat. |
| | + | |
| | + | |
| | | | |
| | ==References== | | ==References== |