Changes

==Prescribing for donkeys==

==Prescribing for donkeys==

 

Pharmacokinetic differences have been demonstrated between horses and donkeys for a number of drugs e.g. oxytetracycline (Horspool ''et al'', 1990), trimethoprim-sulfamethoxazole (Peck ''et al'', 2002), phenylbutazone (Mealey ''et al'', 1997, Matthews ''et al'', 2001), flunixin meglumine (Coakley ''et al'', 1999), and guaifenesin (Matthews ''et al'', 1997) with, in general, Vd being lower, CL being higher and/or t½ being shorter in donkeys than in horses. These differences are of potential clinical significance for some, but not all, drugs that undergo hepatic biotransformation (Peck ''et al'', 1997). The NSAID carprofen is apparently metabolised more slowly in donkeys than in horses (Mealey 'et al'', 2004).

Pharmacokinetic differences have been demonstrated between horses and donkeys for a number of drugs e.g. oxytetracycline (Horspool ''et al'', 1990), trimethoprim-sulfamethoxazole (Peck ''et al'', 2002), phenylbutazone (Mealey ''et al'', 1997, Matthews ''et al'', 2001), flunixin meglumine (Coakley ''et al'', 1999), and guaifenesin (Matthews ''et al'', 1997) with, in general, Vd being lower, CL being higher and/or t½ being shorter in donkeys than in horses. These differences are of potential clinical significance for some, but not all, drugs that undergo hepatic biotransformation (Peck ''et al'', 1997). The NSAID carprofen is apparently metabolised more slowly in donkeys than in horses (Mealey 'et al'', 2004).

approved dose rate and regime.

approved dose rate and regime.

==Drug administration==

==Literature Search==

The parenteral (e.g. intravenous, intramuscular, subcutaneous, intra-articular)

 

or oral routes are used most commonly to administer drugs to donkeys.

Use these links to find recent scientific publications via CAB Abstracts (log in required unless accessing from a subscribing organisation).

<br><br><br>

[http://www.cabdirect.org/search.html?q=(donkey+horse)+AND+subject:(pharmacology) Pharmacology and donkeys and horses publications]

of action <font color='green>(see Table 1)</font color>. Aseptic technique needs to be strictly practised for

sepsis are particularly severe. Drugs can also be applied topically for local

effects. However systemic action can occur following the administration of

administration.

==References==

==References==

|linkpage =Pharmacology - Donkey

|linkpage =Pharmacology - Donkey

|linktext =Pharmacology - Donkey

|linktext =Pharmacology - Donkey

|pagetype=Donkey

|pagetype=Donkey

}}

}}