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[[Image:The_skin_of_a_lizard.jpg|300px|thumb|right|'''The scaly appearance of the skin of the lizard''' (''Lacerta agilis'') (© RVC and its licensors. All rights reserved)]]
Many lizards have quite thick skin while others, such as geckos, have soft, vulnerable skin. The skin undergoes '''ecdysis''' and comes off in a patchwork fashion.
Dewlaps, spines, crests and horns are generally more developed in male lizards.
Chromatophores are responsible for the change of skin colour in species capable of it.
A lateral skin fold between the fore and hind limbs provides a convenient site for the subcutaneous injection of fluid.