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==The inflammatory response==
==The inflammatory response==
[[Image:Donkey picture.JPG|thumb|right|200px|<small><center>Image courtesy of [http://drupal.thedonkeysanctuary.org.uk The Donkey Sanctuary]</center></small>]]
The '''inflammatory response''' is a complex process that occurs '''following cellular injury'''. Cell membrane damage releases '''phospholipids''', which are converted rapidly, mainly '''by phospholipase A2 to arachidonic acid'''. The '''cyclo-oxygenase enzymes (predominantly COX2)''' convert arachidonic acid into '''prostaglandins and thromboxanes''', crucial mediators in the development of <u>inflammation, pain and fever</u>. Prostaglandins and thromboxanes are '''also produced constitutively (COX1)''' and serve numerous <u>homeostatic roles, including protection of the gastric mucosa and kidneys.</u>
The '''inflammatory response''' is a complex process that occurs '''following cellular injury'''. Cell membrane damage releases '''phospholipids''', which are converted rapidly, mainly '''by phospholipase A2 to arachidonic acid'''. The '''cyclo-oxygenase enzymes (predominantly COX2)''' convert arachidonic acid into '''prostaglandins and thromboxanes''', crucial mediators in the development of <u>inflammation, pain and fever</u>. Prostaglandins and thromboxanes are '''also produced constitutively (COX1)''' and serve numerous <u>homeostatic roles, including protection of the gastric mucosa and kidneys.</u>