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− | {{toplink
| + | [[Neospora]] |
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− | |linktext =PARASITES
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− | |sublink1=Protozoa
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− | |subtext1=PROTOZOA
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− | ==Neospora==
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− | *2 main species
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− | **''Neospora caninum'' in the dog
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− | **''Neospora hughesi'' in the horse
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− | *Sporulated oocysts measuring just 10μm
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− | *Oocyst contains 2 sporocysts with 4 sporozoites
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− | *Route of transmission not fully understood
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− | *Often misdiagnosed as ''Toxoplasma gondii''
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− | **''Sarcocystis'' cysts have thicker walls
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− | *Infection diagnosed by IFAT, ELISA or PCR
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− | **Identification of lesions and organisms in tissue using immunohistochemical staining
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− | **Eliminate other causes of abortion first
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− | '''Life cycle'''
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− | *Life cycle similar to ''Toxoplasma gondii''
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− | *Limited range of warm-blooded intermediate hosts
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− | **Asexual reproduction occurs in intermediate host forming tissue cysts
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− | *Host range of sexual stage is unknown for ''N.caninum''
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− | **Intermediate host for ''N.hughesi'' is the horse, but the definitive host is unknown
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− | *Final host
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− | **Dogs pass oocysts
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− | **Role not fully understood in pathogenesis
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− | **5 day prepatent period
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− | **Other wild canids may also act as final definitive hosts
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− | *Intermediate host
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− | **Mostly cattle
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− | **Natural infection has been documented in other herbivores
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− | *Transmission
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− | **Transplacental infection occurs in all intermediate hosts and in the canine final host
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− | ***Transplacental transmission can occur in '''successive pregnancies'''
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− | **In cattle, vertical transmission occurs
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− | ***Post-natal infection occurs but is less common
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− | '''Pathogenesis'''
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− | *Dogs
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− | **Occurs mainly in puppies
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− | **Causes ascending paralysis, especially of hind limbs, with muscle wasting
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− | **Causes sudden collapse due to myocarditis
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− | **More than 1 puppy in a litter may be affected, although this may not occur simultaneously
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− | **Successive litters affected
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− | *Cattle
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− | **Commonest cause of infectious abortion in dairy cattle
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− | **Congenitally infected calves can have encephalomyelitis and paresis
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− | **Abortion usually occurs between 5-7 months of gestation but can occur as early as 3 months
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− | **No other clinical signs in the cow
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− | **Repeat abortions possible in same cow (persistently infected)
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− | *Horses
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− | **Myeloencephalitis
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− | **Transplacental infection occurs
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− | **Disease only diagnosed in USA
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− | *''Neospora caninum'' in [[Muscles Inflammatory - Pathology#Protozoa|myositis]]
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− | '''Prevention and Control'''
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− | *Do not allow dogs access to calving cows, placental membranes and aborted or dead calves
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− | *Do not allow dogs to defecate in cattle feeding areas
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− | *Identify and cull seropositive cattle, or do not breed from them or their progeny
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− | *Select seronegative cattle for breeding
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− | *Vaccinate
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− | **Only in the USA
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− | **Neoguard or Intervet
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− | **Killed protozoal vaccine for healthy, pregnant cows
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− | **Dosed in first 3 weeks of pregnancy and then every 3-4 weeks during gestation
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− | **Revaccination with 2 doses during each subsequent pregnancy
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| ==Sarcocystis== | | ==Sarcocystis== |
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| ==[[Protozoa Flashcards - Wikibugs#Tissue Cyst Forming Coccidia|Tissue Cyst Forming Coccidia Flashcards]]== | | ==[[Protozoa Flashcards - Wikibugs#Tissue Cyst Forming Coccidia|Tissue Cyst Forming Coccidia Flashcards]]== |
| + | [[Category:Piroplasmida]] |