Changes

==The renal portal system==

==The renal portal system==

Reptiles have a renal portal system where venous return from the tail and hindlimbs may be filtered through the kidneys to bathe the renal tubules. Venous return from the tail and hindlimbs may be filtered through the kidney or liver. When filtered through the kidney, the blood bathes the renal tubules.

Reptiles have a renal portal system where venous return from the tail and hindlimbs may be filtered through the kidneys to bathe the renal tubules. Venous return may also be filtered through the liver.

* The [[Lizard Injection|injection]] of drugs that are cleared via tubular excretion into the caudal half of the body could result in lower than anticipated serum concentration because of their excretion in the urine before entering the systemic circulation. This could potentially result in increased renal toxicity when using nephrotoxic drugs (eg. aminoglycosides); however the results of limited pharmacokinetic studies suggest that the renal portal system has less effect on drug uptake and distribution than previously thought. Furthermore, shunts exist that carry blood directly from the renal portal system to the postcava, bypassing the renal parenchyma.

* The [[Lizard Injection|injection]] of drugs that are cleared via tubular excretion into the caudal half of the body could result in lower than anticipated serum concentration because of their excretion in the urine before entering the systemic circulation. This could potentially result in increased renal toxicity when using nephrotoxic drugs (eg. aminoglycosides); however the results of limited pharmacokinetic studies suggest that the renal portal system has less effect on drug uptake and distribution than previously thought. Furthermore, shunts exist that carry blood directly from the renal portal system to the postcava, bypassing the renal parenchyma.