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Created page with '*Causes melioidosis - endemic in Asia and Australia *Primarily infects rodents *Pathogenesis: **Infe…'
*Causes [[Respiratory Bacterial Infections - Pathology#Melioidosis (Pseudoglanders)|melioidosis]] - endemic in Asia and Australia
*Primarily infects rodents
*Pathogenesis:
**Infection via ingestion, inhalation or skin wounds from environment
**Exotoxin, dermonecrotic protease and lecithinase implicated in pathogenicity
**Strain virulence and host immunosuppression important
*Clinical infections:
**Opportunistic infection with stress and immunosuppression predisposing to disease
**Abscesses develop in many organs including lungs, spleen, liver, joints, CNS, upper respiratory tract
**Chronic, debilitating, progressive disease with long incubation period
**Many animal species susceptible
**Referred to as pseudoglanders in horses
*Diagnosis:
**Specimens: pus from abscesses, affected tissues, blood
**Fluorescent antibody technique on tissue smears
**Blood agar and MacConkey agar plates, incubated aerobically
**Colonies have musty smell
**Lactose fermentation on MacConkey
**Slide agglutination
**ELISA, complement fixation and indirect haemagglutination tests for serum antibodies
*Treatment/control: slaughter of infected animals where exotic[[Category:Pseudomonas_and_Burkholderia_species]][[Category:Rodents]]
*Primarily infects rodents
*Pathogenesis:
**Infection via ingestion, inhalation or skin wounds from environment
**Exotoxin, dermonecrotic protease and lecithinase implicated in pathogenicity
**Strain virulence and host immunosuppression important
*Clinical infections:
**Opportunistic infection with stress and immunosuppression predisposing to disease
**Abscesses develop in many organs including lungs, spleen, liver, joints, CNS, upper respiratory tract
**Chronic, debilitating, progressive disease with long incubation period
**Many animal species susceptible
**Referred to as pseudoglanders in horses
*Diagnosis:
**Specimens: pus from abscesses, affected tissues, blood
**Fluorescent antibody technique on tissue smears
**Blood agar and MacConkey agar plates, incubated aerobically
**Colonies have musty smell
**Lactose fermentation on MacConkey
**Slide agglutination
**ELISA, complement fixation and indirect haemagglutination tests for serum antibodies
*Treatment/control: slaughter of infected animals where exotic[[Category:Pseudomonas_and_Burkholderia_species]][[Category:Rodents]]