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| | *Inoculation of susceptible animals | | *Inoculation of susceptible animals |
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| − | | + | [[Rickettsia rickettsii]] |
| − | ===Rocky Mountain spotted fever===
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| − | *Caused by ''Rickettsia rickettsii''
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| − | *Affects humans and dogs
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| − | *Various tick vectors, which acquire the organism from small mammals
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| − | *Transovarial and trans-stadial transmission within the tick population
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| − | *Organisms replicate in endothelial cells of infected dogs, cause vasculitis, increased vascular permeability and haemorrhage
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| − | *Clinical signs
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| − | **Incubation period 2-10 days; course less than 2 weeks
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| − | *Fever, depression, conjunctivitis, retinal haemorrhage, muscle and joint pain, coughing, dyspnoea, oedema of extremities
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| − | *Neurological signs in dogs include stupor, ataxia, neck rigidity, seizures and coma
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| − | *Death from cardiovascular, neurological or renal damage in severely-affected animals
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| − | *Gross pathology includes haemorrhage, splenomegaly and lymphadenopathy
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| − | *Diagnosis
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| − | **Rising antibody titre during an indirect fluorescent antibody test or ELISA
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| − | **Thrombocytopenia and leukopenia during early phase
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| − | | |
| − | *Treatment and control
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| − | **Tetracycline therapy for two weeks
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| − | **Tick removal from dogs
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