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*Host and cell type specificity
*Host and cell type specificity
*Q fever and Rocky Mountain spotted fever are zoonoses
*Q fever and Rocky Mountain spotted fever are zoonoses
===Characteristics===
===Characteristics===
*''Rickettsiaceae'' have cell walls that contain peptidoglycan; they target endothelial cells and leukocytes
*''Rickettsiaceae'' have cell walls that contain peptidoglycan; they target endothelial cells and leukocytes
*''Anaplasmataceae'' lack cell walls; they target erythrocytes
*''Anaplasmataceae'' lack cell walls; they target erythrocytes
===Epidemiology===
===Epidemiology===
*Transovarial or trans-stadial transmission occurs in the arthropod vectors
*Transovarial or trans-stadial transmission occurs in the arthropod vectors
*Most ricketsiae have limited survival in the environment, apart from ''Coxiella burnetii'', which undergoes aerosol transmission
*Most ricketsiae have limited survival in the environment, apart from ''Coxiella burnetii'', which undergoes aerosol transmission
===Pathogenesis and pathogenicity===
===Pathogenesis and pathogenicity===
*''Ehrlichia'' target leukocytes or platelets, and inhibit phagosome/lysosome fusion
*''Ehrlichia'' target leukocytes or platelets, and inhibit phagosome/lysosome fusion
*''Anaplasmataceae'' localise within vacuoles or on the surface of red blood cells; they may alter red cell antigens causing immune-mediated damage. Anaemia may result from haemolysis or removal of red blood cells
*''Anaplasmataceae'' localise within vacuoles or on the surface of red blood cells; they may alter red cell antigens causing immune-mediated damage. Anaemia may result from haemolysis or removal of red blood cells
===Identification===
===Identification===
[[Ehrlichia canis]]
[[Ehrlichia canis]]
[[Ehrlichia platys]]