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**Cattle and sheep
***Cattle are maintenance hosts for ''L. borgpetersenii'' serovar ''hardjo''
***''L. interrogans'' serovar ''hardjo'' is host-adapted to cattle
***Acute disease in susceptible heifers, with fever and agalactia of all quarters; abortion and stillbirth may occur
***Diagnosed by rising antibody titre in paired serum samples
***Infection in sheep may cause abortion and agalactia
***Urinary excretion can be reduced by administering dihydrostreptomycin or amoxycillin
***Incactivated vaccines are of questionable efficacy
***Serovars ''pomona, grippotyphosa'' and ''icterohaemorrhagiae'' cause pyrexia, haemoglobinurea, jaundice, anorexia, uraemia due to renal damage and death in calves and lambs