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Created page with 'Causes Infectious canine tracheitis ====Hosts==== *Dogs *Foxes are very susceptible (Fox Encephalitis) ====Pathogenesis==== *Infects and replicates in the oropharynx *Viremia a…'
Causes Infectious canine tracheitis
====Hosts====
*Dogs
*Foxes are very susceptible (Fox Encephalitis)
====Pathogenesis====
*Infects and replicates in the oropharynx
*Viremia as the virus reaches endothelial cells
*Attacks the endothelial lining of '''gall bladder''', '''liver sinusoids''', and '''Kuppfer cells'''
*Resulting '''heptatitis''' is followed by severe abdominal pain and often death
*Post Mortem: swollen, hemorrhagic liver, ascites, and oedema of the gall bladder
*In older dogs, may present more mildly with lymph node enlargement and chronic interstitial nephritis
*In foxes: virus replicates in the endothelia of the brain resulting in neuronal damage, fits, and paralysis
====Epidemiology====
*Transfers '''easily''' via ingesting infected '''urine, feces or respiratory secretions'''
*Can be transferred by handlers, infected surfaces, etc.
====Diagnosis====
*Intranuclear inclusion bodies in hepatocytes can be seen under H&E staining
*Vascular endothelium can be stained for viral '''antigen''' by '''immunofluorescence'''
====Control====
In an outbreak
*Isolate infected dogs
*Disinfect premises
To prevent
*'''Vaccination''': tissue culture adaptation that may be live or inactivated
*Cross protection with CAV2
*Live vaccines are known to cause keratitis in Afghans, Red Setters and Saluki
[[Category:Adenoviridae]][[Category:Dog]]
====Hosts====
*Dogs
*Foxes are very susceptible (Fox Encephalitis)
====Pathogenesis====
*Infects and replicates in the oropharynx
*Viremia as the virus reaches endothelial cells
*Attacks the endothelial lining of '''gall bladder''', '''liver sinusoids''', and '''Kuppfer cells'''
*Resulting '''heptatitis''' is followed by severe abdominal pain and often death
*Post Mortem: swollen, hemorrhagic liver, ascites, and oedema of the gall bladder
*In older dogs, may present more mildly with lymph node enlargement and chronic interstitial nephritis
*In foxes: virus replicates in the endothelia of the brain resulting in neuronal damage, fits, and paralysis
====Epidemiology====
*Transfers '''easily''' via ingesting infected '''urine, feces or respiratory secretions'''
*Can be transferred by handlers, infected surfaces, etc.
====Diagnosis====
*Intranuclear inclusion bodies in hepatocytes can be seen under H&E staining
*Vascular endothelium can be stained for viral '''antigen''' by '''immunofluorescence'''
====Control====
In an outbreak
*Isolate infected dogs
*Disinfect premises
To prevent
*'''Vaccination''': tissue culture adaptation that may be live or inactivated
*Cross protection with CAV2
*Live vaccines are known to cause keratitis in Afghans, Red Setters and Saluki
[[Category:Adenoviridae]][[Category:Dog]]