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*Vaccination can lead to '''iatrogenic''' infection in undiagnosed PI calves
*Vaccination can lead to '''iatrogenic''' infection in undiagnosed PI calves
====Pathology====
*'''Mucosal Disease''': erosive condition produces small multiple, cleanly punched out lesion in mouth
*[[Neutrophils - WikiBlood|Neutrophils]] invade the ulcer and if bacterial colonisation occurs, further excavation follows. Either:
::#This lesion develops a granular base and becomes diphtheritic.
::#If bacterial colonisation does not take place, healing occurs within fourteen days.
*Seen in most parts of mouth (or maybe on muzzle) e.g. dental pad, [[Cheeks - Anatomy & Physiology|cheeks]], sides of [[Oral Cavity - Tongue - Anatomy & Physiology|tongue]]
*Lesions extend throughout gut with particularly big ulcers in small intestine over [[Peyer's Patches - Anatomy & Physiology|Peyers patches]]. Necrosis occurs in lymph nodes and [[Spleen - Anatomy & Physiology|spleen]]
====<span id="BVDHistology">Histology</span>====
*No vesicular stage, prickle cells die off from surface resulting in layer of necrotic debris over epithelial layer
*Infection penetrates inward through stratum germinativum.
*Epithelium does not recover as animal does not recover
====Epidemiology====
====Epidemiology====
*A major concern is that it can be confused with [[Foot and Mouth Disease (FMDV)|FMD]] (especially as it often occurs with clinical signs of salivation and depression)
*A major concern is that it can be confused with [[Foot and Mouth Disease (FMDV)|FMD]] (especially as it often occurs with clinical signs of salivation and depression)
**Combine with screening for antigen and removal of PI animals
**Combine with screening for antigen and removal of PI animals
[[Category:Pestiviruses]][[Category:Cattle]]
[[Category:Pestiviruses]][[Category:Cattle]]
[[Category:Oral_Cavity_-_Erosive_&_Ulcerative_Pathology]]