#Initially - hyperaemia of mucosa (e.g. catarrhal inflammation) then within 12 hours produces fluid filled vesicles on dorsum of [[Oral Cavity - Tongue - Anatomy & Physiology|tongue]], may be other places
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#Small vesicle coalesce to produce big ones -i.e. Bullae
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#Very quickly rupture; epithelium appears dirty grey in colour because of necrosis - sloughed skin, very good for diagnosis
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#Leave painful, hyperaemic epithelium
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#Looks like "ulcer "with ragged edge but not a true ulcer as stratum germinativum retained and will rapidly heal completely in about 2 weeks unless becomes secondarily infected
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=====Microscopic lesions=====
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*Degeneration of prickle cells
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*Cells "balloon" as fill with fluid and then die to produce vesicle containing straw coloured or clear fluid