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| | **Microscopically: lichenoid interface dermatitis, often with lymphocytes, plasma cells, basal cell degeneration, loss of pigment | | **Microscopically: lichenoid interface dermatitis, often with lymphocytes, plasma cells, basal cell degeneration, loss of pigment |
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| − | ===Pemphigus=== | + | ===[[Pemphigus]]=== |
| − | | |
| − | *Blistering diseases
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| − | *Autoantibodies bind to desmosomal proteins -> cell adhesion disrupted -> vesicles
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| − | *Types:
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| − | **'''Pemphigus vulgaris'''
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| − | ***Rare, severe form
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| − | ***Cats and dogs
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| − | ***Vesicles or bullae -> erosions and ulcers
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| − | ***Involves oral cavity, mucocutaneous junctions and skin
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| − | ***Microscopically:
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| − | ****Suprabasilar vesiculation and row of basal cells adhering to basement membrane
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| − | ****Superficial perivascular dermatitis
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| − | **'''Pemphigus vegetans'''
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| − | ***Rare
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| − | ***Dogs
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| − | ***Involves the trunk
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| − | ***Mild version of P. vulgaris
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| − | ***Vesicopustular dermatitis + epidermal hyperplasia -> papillomatous formations
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| − | **'''Pemphigus foliaceus'''
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| − | ***More common
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| − | ***Cats, dogs, horses, goats
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| − | ***Localised lesions or generalised
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| − | ***Symmetrical vesicular or pustular dermatitis, crusts, scales, alopecia
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| − | ***Microscopically:
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| − | ****Acantholytic cells
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| − | ****Subcorneal or intragranular pustules
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| − | ****In third of equine or canine cases [[Eosinophils - WikiBlood|eosinophils]] are predominant
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| − | **'''Pemphigus erythematosus'''
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| − | ***Cats and dogs
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| − | ***Mild form of P. foliaceus
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| − | ***Usually involves only face and external ears
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