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====Orf====
 
====Orf====
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====Bovine Papular stomatitis====
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====[[Bovine Papular Stomatitis]]====
Papular proliferative pathology
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[[Image:BPS.gif|right|thumb|125px|<small><center>Ring Zone Lesions of BPS - Calf (Courtesy of Alun Williams (RVC))</center></small>]]
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*Parapox virus
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*Very similar disease to orf but seen in cattle and generally milder condition. 
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*'''Must be differentiated from [[#Foot and Mouth disease|Foot and Mouth Disease]] and [[#Bovine Viral Diarrhoea / Mucosal disease|Mucosal Disease.]]'''
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*Sporadic, in cattle, less than 1 year old.
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*Develop papules on the muzzle, external nares and in the [[Oral Cavity Overview - Anatomy & Physiology|oral cavity]]; the [[Oesophagus - Anatomy & Physiology|oesophagus]] and [[Stomach and Abomasum - Anatomy & Physiology|forestomachs]] may also be affected. 
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*Usually heals spontaneously.
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=====Pathogenesis=====
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*The early lesions are round areas of intense congestion up to 1.5 cm in diameter.
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*The centre becomes necrotic and slightly depressed.
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*Slow peripheral extension of this lesion gives a classical ring zone formation with concentric rings of
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**yellow (necrosis),
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**grey (epithelial hyperplasia)
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**red (congestion).
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=====Histology=====  
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*There are focal areas of hydropic degeneration in the stratum spinosum
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*Large eosinophilic intracytoplasmic inclusion
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*Epidermis is markedly thickened.
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*The superficial layers of the epithelium become necrotic and slough.
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*''Vesicle formation is not a feature of this disease.''
      
====Papilloma====
 
====Papilloma====
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