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Created page with 'Papular proliferative pathology right|thumb|125px|<small><center>Ring Zone Lesions of BPS - Calf (Courtesy of Alun Williams (RVC))</center></small> *Parapox vir…'
Papular proliferative pathology
[[Image:BPS.gif|right|thumb|125px|<small><center>Ring Zone Lesions of BPS - Calf (Courtesy of Alun Williams (RVC))</center></small>]]
*Parapox virus
*Very similar disease to orf but seen in cattle and generally milder condition.
*'''Must be differentiated from [[#Foot and Mouth disease|Foot and Mouth Disease]] and [[#Bovine Viral Diarrhoea / Mucosal disease|Mucosal Disease.]]'''
*Sporadic, in cattle, less than 1 year old.
*Develop papules on the muzzle, external nares and in the [[Oral Cavity Overview - Anatomy & Physiology|oral cavity]]; the [[Oesophagus - Anatomy & Physiology|oesophagus]] and [[Stomach and Abomasum - Anatomy & Physiology|forestomachs]] may also be affected.
*Usually heals spontaneously.
=====Pathogenesis=====
*The early lesions are round areas of intense congestion up to 1.5 cm in diameter.
*The centre becomes necrotic and slightly depressed.
*Slow peripheral extension of this lesion gives a classical ring zone formation with concentric rings of
**yellow (necrosis),
**grey (epithelial hyperplasia)
**red (congestion).
=====Histology=====
*There are focal areas of hydropic degeneration in the stratum spinosum
*Large eosinophilic intracytoplasmic inclusion
*Epidermis is markedly thickened.
*The superficial layers of the epithelium become necrotic and slough.
*''Vesicle formation is not a feature of this disease.''
[[Category:Poxviridae]][[Category:Oral_Cavity_-_Proliferative_Pathology]][[Category:Cattle]]
[[Image:BPS.gif|right|thumb|125px|<small><center>Ring Zone Lesions of BPS - Calf (Courtesy of Alun Williams (RVC))</center></small>]]
*Parapox virus
*Very similar disease to orf but seen in cattle and generally milder condition.
*'''Must be differentiated from [[#Foot and Mouth disease|Foot and Mouth Disease]] and [[#Bovine Viral Diarrhoea / Mucosal disease|Mucosal Disease.]]'''
*Sporadic, in cattle, less than 1 year old.
*Develop papules on the muzzle, external nares and in the [[Oral Cavity Overview - Anatomy & Physiology|oral cavity]]; the [[Oesophagus - Anatomy & Physiology|oesophagus]] and [[Stomach and Abomasum - Anatomy & Physiology|forestomachs]] may also be affected.
*Usually heals spontaneously.
=====Pathogenesis=====
*The early lesions are round areas of intense congestion up to 1.5 cm in diameter.
*The centre becomes necrotic and slightly depressed.
*Slow peripheral extension of this lesion gives a classical ring zone formation with concentric rings of
**yellow (necrosis),
**grey (epithelial hyperplasia)
**red (congestion).
=====Histology=====
*There are focal areas of hydropic degeneration in the stratum spinosum
*Large eosinophilic intracytoplasmic inclusion
*Epidermis is markedly thickened.
*The superficial layers of the epithelium become necrotic and slough.
*''Vesicle formation is not a feature of this disease.''
[[Category:Poxviridae]][[Category:Oral_Cavity_-_Proliferative_Pathology]][[Category:Cattle]]