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Upper Alimentary Tract Carcinoma Complex (view source)
Revision as of 11:32, 28 May 2010
, 11:32, 28 May 2010Created page with '=====Aetiology===== *The most important oesophageal neoplasm is squamous cell carcinoma in the cow. *This tumou…'
=====Aetiology=====
*The most important [[Oesophagus - Anatomy & Physiology|oesophageal]] neoplasm is [[Squamous Cell Carcinoma|squamous cell carcinoma]] in the cow.
*This tumour is seen as part of a more general syndrome of upper alimentary tract neoplasia in adult cattle grazing rough pasture on which the '''bracken fern''' (Pteridium aquilinum) is present.
*The syndrome is seen in various part of the world including the Western Highlands of Scotland, Brazil and Kenya.
*In affected animals, squamous carcinomas may be present in the [[Oral Cavity - Oropharynx - Anatomy & Physiology|oropharynx]], [[Oesophagus - Anatomy & Physiology|oesophagus]] and [[The Rumen - Anatomy & Physiology|rumen]] and there may also be [[intestinal adenocarcinomas]] and bladder tumours, or the condition known as [[enzootic bovine haematuria]].
=====Pathogenesis=====
*Experimentally, the feeding of bracken to laboratory animals will result in alimentary and [[Urinary Bladder - Anatomy & Physiology|bladder]] tumours.
*However, in many naturally-occurring cases of upper alimentary carcinoma in cattle there are coexisting viral papillomata, some of which show malignant change.
*The relationship between the ingestion of bracken and the presence of virus in the aetiology of the malignancies is currently the subject of intensive investigations.
*It may be that both are involved in the carcinogenesis.
=====Macroscopically=====
*These upper alimentary squamous carcinomas are most often seen as:
**large
**fungating
**often superficially-necrotic
**protruding into the lumen of the [[Alimentary - Anatomy & Physiology|alimentary tract]];
*There is often a marked scirrhous reaction.
*The tumours are locally aggressive and may permeate local lymphatics and metastasise to local lymph nodes.
=====Microscopically=====
The tumour consists of cords or groups of squamous cells, which may form keratin.
Individual or multiple papillomata may be found in association with the carcinomata.
*The presence of the tumours interferes with normal alimentary function
**there may be difficulty in chewing and [[Deglutition|swallowing]] or in cudding and [[Eructation - Anatomy & Physiology|eructation]].[[Category:Oesophagus_-_Pathology]][[Category:Cattle]]
*The most important [[Oesophagus - Anatomy & Physiology|oesophageal]] neoplasm is [[Squamous Cell Carcinoma|squamous cell carcinoma]] in the cow.
*This tumour is seen as part of a more general syndrome of upper alimentary tract neoplasia in adult cattle grazing rough pasture on which the '''bracken fern''' (Pteridium aquilinum) is present.
*The syndrome is seen in various part of the world including the Western Highlands of Scotland, Brazil and Kenya.
*In affected animals, squamous carcinomas may be present in the [[Oral Cavity - Oropharynx - Anatomy & Physiology|oropharynx]], [[Oesophagus - Anatomy & Physiology|oesophagus]] and [[The Rumen - Anatomy & Physiology|rumen]] and there may also be [[intestinal adenocarcinomas]] and bladder tumours, or the condition known as [[enzootic bovine haematuria]].
=====Pathogenesis=====
*Experimentally, the feeding of bracken to laboratory animals will result in alimentary and [[Urinary Bladder - Anatomy & Physiology|bladder]] tumours.
*However, in many naturally-occurring cases of upper alimentary carcinoma in cattle there are coexisting viral papillomata, some of which show malignant change.
*The relationship between the ingestion of bracken and the presence of virus in the aetiology of the malignancies is currently the subject of intensive investigations.
*It may be that both are involved in the carcinogenesis.
=====Macroscopically=====
*These upper alimentary squamous carcinomas are most often seen as:
**large
**fungating
**often superficially-necrotic
**protruding into the lumen of the [[Alimentary - Anatomy & Physiology|alimentary tract]];
*There is often a marked scirrhous reaction.
*The tumours are locally aggressive and may permeate local lymphatics and metastasise to local lymph nodes.
=====Microscopically=====
The tumour consists of cords or groups of squamous cells, which may form keratin.
Individual or multiple papillomata may be found in association with the carcinomata.
*The presence of the tumours interferes with normal alimentary function
**there may be difficulty in chewing and [[Deglutition|swallowing]] or in cudding and [[Eructation - Anatomy & Physiology|eructation]].[[Category:Oesophagus_-_Pathology]][[Category:Cattle]]