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| The different compartments of the ruminant stomach develop from the foregut spindle in foetal life. During embyogenesis and after birth the [[The Abomasum - Anatomy & Physiology|abomasum]] is the largest of the compartments (over half of the weight and capacity of the four stomachs) due to the [[oesophageal groove|Oesophageal Groove]] directing milk from the oesophagus to the [[The Rumen - Anatomy & Physiology|rumen]] into the [[The Abomasum - Anatomy & Physiology|abomasum]], bypassing the [[The Reticulum - Anatomy & Physiology|reticulum]]. | | The different compartments of the ruminant stomach develop from the foregut spindle in foetal life. During embyogenesis and after birth the [[The Abomasum - Anatomy & Physiology|abomasum]] is the largest of the compartments (over half of the weight and capacity of the four stomachs) due to the [[oesophageal groove|Oesophageal Groove]] directing milk from the oesophagus to the [[The Rumen - Anatomy & Physiology|rumen]] into the [[The Abomasum - Anatomy & Physiology|abomasum]], bypassing the [[The Reticulum - Anatomy & Physiology|reticulum]]. |
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| + | * In most animals, after swallowing, food leaves the [[Oesophagus - Anatomy & Physiology|oesophagus]] and enters the [[Forestomach - Anatomy & Physiology|stomach]]. In ruminants, food enters the [[The Abomasum - Anatomy & Physiology|abomasum]] after fermentation in the forestomach. |
| + | * The [[Forestomach - Anatomy & Physiology|stomach]] acts as a reservoir in which a semi-solid mass (chyme) is formed from the ingested food before passing into the [[Duodenum - Anatomy & Physiology|duodenum]]. |
| + | * With the exception of water, little absorption occurs in the [[Forestomach - Anatomy & Physiology|stomach]]. |
| + | * Gastric juice is highly acidic, and contains: |
| + | ** HCl, produced by the parietal cells |
| + | *** Maintains gastric pH at 2, which denatures protein. |
| + | ** Pepsin, derived from pepsinogen, produced by zymogen cells |
| + | *** The action of HCl facilitates this. |
| + | * Surface epithelial cells and mucous neck cells produce mucus which forms an alkaline sheet over the epithelial surface. |
| + | ** Provides protection from the gastric juice. |
| + | * The cells of the mucosa are renewed at different rates. This is an important considerination in the pathogenesis of certain gastric diseases. |
| + | ** Surface epithelial cells and mucous neck cells are replaced about every 3 days. |
| + | ** Parietal cells and zymogen cells are produced at a slower rate; the parietal cells have a half-life of 23 days. |
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| + | ===Defence Mechanisms=== |
| + | # Secretions : |
| + | #* Mucus (inhibits contact with mucosa, protects surface). |
| + | #* Acid (parietal cells) |
| + | #* Digestive enzymes (pepsin from gastric chief cells) |
| + | # Epithelium: |
| + | #* Provides a barrier |
| + | #** Stratified squamous epithelium; multilayered, high cell turnover |
| + | # Movement: |
| + | #* Continuous movement discourages persistence of insult at mucosa. |
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| [[The Rumen - Anatomy & Physiology|The Rumen]] | | [[The Rumen - Anatomy & Physiology|The Rumen]] |