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Created page with '* '''Catarrhal gastritis is an important characterisitic of this condition''' * Oedema disease is a sporadic condition that can become important on some …'
* '''[[Gastritis, Catarrhal|Catarrhal gastritis]] is an important characterisitic of this condition'''
* Oedema disease is a sporadic condition that can become important on some farms.
====Clinical====
* Generally occurs in young pigs, though sometimes in older pigs
** 7-10 days after major change in diet e.g. weaning.
* Signs include
** '''No''' [[Intestine Diarrhoea - Pathology|diarrhoea]]
** Puffy eyelids
** High-pitched voice (oedema of larynx)
** Sitting on haunched
** "Star-gazing" due to cerebral oedema (hallucinations?).
* Animals usually die.
* Disease develops very quickly so pigs do not have time to go off food.
====Pathogenesis====
* Oedema disease is an enterotoxaemia associated with infection by enterotoxigenic [[Escherichia coli|''E.coli'']].
* Verotoxin/ shiga toxin- producing ''E. coli'' proliferate in the [[Small Intestine - Anatomy & Physiology|small intestine]]
** Especially O138, O139, and O141.
** Organisms remain in the gut (are not invasive).
* Labile shiga-like toxin II is absorbed into body, producing effects everywhere.
* Blood vessel walls are damaged and become very leaky, producing oedema everywhere.
** Histological blood vessel changes are subtle.
** Fibrinoid degeneration of media in small arteries.
====Pathology====
* An important characteristic of oedema disease is the occurrence of catarrhal gastritis and marked oedema in the [[Forestomach - Anatomy & Physiology|stomach]] mucosa and wall.
* Also oedema of various organs, particularly between coils of spiral [[Colon - Anatomy & Physiology|colon]].
====Diagnosis====
* Clinical signs are characteristic.
* Also by culture and typing of ''E. coli'' from gut
[[Category:Stomach_and_Abomasum_-_Inflammatory_Pathology]][[Category:Pig]]
* Oedema disease is a sporadic condition that can become important on some farms.
====Clinical====
* Generally occurs in young pigs, though sometimes in older pigs
** 7-10 days after major change in diet e.g. weaning.
* Signs include
** '''No''' [[Intestine Diarrhoea - Pathology|diarrhoea]]
** Puffy eyelids
** High-pitched voice (oedema of larynx)
** Sitting on haunched
** "Star-gazing" due to cerebral oedema (hallucinations?).
* Animals usually die.
* Disease develops very quickly so pigs do not have time to go off food.
====Pathogenesis====
* Oedema disease is an enterotoxaemia associated with infection by enterotoxigenic [[Escherichia coli|''E.coli'']].
* Verotoxin/ shiga toxin- producing ''E. coli'' proliferate in the [[Small Intestine - Anatomy & Physiology|small intestine]]
** Especially O138, O139, and O141.
** Organisms remain in the gut (are not invasive).
* Labile shiga-like toxin II is absorbed into body, producing effects everywhere.
* Blood vessel walls are damaged and become very leaky, producing oedema everywhere.
** Histological blood vessel changes are subtle.
** Fibrinoid degeneration of media in small arteries.
====Pathology====
* An important characteristic of oedema disease is the occurrence of catarrhal gastritis and marked oedema in the [[Forestomach - Anatomy & Physiology|stomach]] mucosa and wall.
* Also oedema of various organs, particularly between coils of spiral [[Colon - Anatomy & Physiology|colon]].
====Diagnosis====
* Clinical signs are characteristic.
* Also by culture and typing of ''E. coli'' from gut
[[Category:Stomach_and_Abomasum_-_Inflammatory_Pathology]][[Category:Pig]]