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| − | ==Villus Atrophy== | + | {{frontpage |
| − | | + | |pagetitle =Enteritis, Villus Atrophy |
| − | * Commonly seen in enteric disease. | + | |pagebody = * Commonly seen in enteric disease. |
| | * Occurs when more enterocytes are lost than are produced in the crypts. | | * Occurs when more enterocytes are lost than are produced in the crypts. |
| | * Causes malabsorption of nutrients and water. | | * Causes malabsorption of nutrients and water. |
| − | * There are two main types of villus atrophy: | + | * There are two main types of villus atrophy, with and without damage to the crypts. |
| − | | + | |contenttitle =Content |
| − | ===Villus atrophy with intact/hypertrophic crypt glands===
| + | |contentbody =<big><b> |
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| − | * Insult affects the villus enterocytes leading to increased loss.
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| − | ** Under mild insult, villi may fully regenerate.
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| − | ** Severe insult leads to immature cells on the villus.
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| − | *** Secrete water and electrolytes into lumen.
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| − | * Examples include:
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| − | ** '''Rotavirus, Coronavirus'''
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| − | *** Infect villus enterocytes.
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| − | ** '''Coccidia'''
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| − | *** Infect surface enterocytes.
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| − | ** '''Nematodes'''
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| − | *** Abrase surface.
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| − | ===Villus atrophy with damage to crypts===
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| − | * The primary insult is to crypt cells.
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| − | ** Crypt cell death leads to dilated gland lumens (cysts).
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| − | ** Production is impaired, eventually leading to insufficient cells for villi.
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| − | * Enterocytes lost to lumen are replaced by increasingly immature cells.
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| − | ** Gives rise to severe malabsorption.
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| − | * If damage is severe, erosions/ulcers may form which may eventually heal.
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| − | ** Even if there are no ulcers, damage can be long-term
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| − | *** Causes long-term malabsorption.
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| − | * Examples include:
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| − | ** '''Parvovirus'''
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| − | *** Target crypt cells.
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| − | ** '''Lymphoma'''
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| − | *** Numerous neoplastic lymphocytes compress crypts.
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| − | ** '''Cytotoxic chemicals'''
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| − | *** Dividing crypt cells are susceptible.
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| − | ==Enteritis Particularly Associated with Villus Atrophy==
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| − | ===[[Reoviridae#Rotaviruses|Rotavirus]]===
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| − | ===[[Cryptosporidium|Cryptosporidium]]===
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| | + | <categorytree mode=pages>Enteritis, Villus Atrophy</categorytree> |
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| | + | </b></big> |
| | + | |logo =path-logo.png |
| | + | }} |
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| | [[Category:Intestine_-_Inflammatory_Pathology_by_Type]] | | [[Category:Intestine_-_Inflammatory_Pathology_by_Type]] |