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Enterocytes, Epithelial Renewal (view source)
Revision as of 11:09, 6 June 2010
, 11:09, 6 June 2010Created page with '* Enterocytes are usually shed after 2-8 days. * To replace enterocytes. epithelial progenitor cells in the crypts of the [[Small Intestine - Anatomy & Physiology|small intestine…'
* Enterocytes are usually shed after 2-8 days.
* To replace enterocytes. epithelial progenitor cells in the crypts of the [[Small Intestine - Anatomy & Physiology|small intestine]] continually divide.
** New epithelial cells move up towards the surface (i.e. the tip of the villus).
** As cells move up, they differentiate and lose the ability to divide.
* When epithelial cells are lost (rather than shed), the damage is repaired.
** Minor loss results in the lateral migration of adjacent cells.
*** Repair within minutes.
** More major loss results in contraction of the villus, and cells migrate across intercrypt surface.
* Epithelial renewal is in a state of '''dynamic equilibrium'''.
** Enterocyte production in crypts = shedding from villus tip into lumen.
*Disruption of this equilibrium by any disease can cause lesions of the mucosa and villi.
** E.g. '''villus atrophy'''.
[[Category:Enteritis,_Villus_Atrophy]][[Category:WikiPath]]
* To replace enterocytes. epithelial progenitor cells in the crypts of the [[Small Intestine - Anatomy & Physiology|small intestine]] continually divide.
** New epithelial cells move up towards the surface (i.e. the tip of the villus).
** As cells move up, they differentiate and lose the ability to divide.
* When epithelial cells are lost (rather than shed), the damage is repaired.
** Minor loss results in the lateral migration of adjacent cells.
*** Repair within minutes.
** More major loss results in contraction of the villus, and cells migrate across intercrypt surface.
* Epithelial renewal is in a state of '''dynamic equilibrium'''.
** Enterocyte production in crypts = shedding from villus tip into lumen.
*Disruption of this equilibrium by any disease can cause lesions of the mucosa and villi.
** E.g. '''villus atrophy'''.
[[Category:Enteritis,_Villus_Atrophy]][[Category:WikiPath]]