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*Neutropenia every 2 weeks which lasts 3-4 days due to cyclic production of cells from [[Bone Marrow - Anatomy & Physiology|bone marrow]]
*Neutropenia every 2 weeks which lasts 3-4 days due to cyclic production of cells from [[Bone Marrow - Anatomy & Physiology|bone marrow]]
*Animals are prone to recurrent infections, mainly from the respiratory and gastrointestinal tract
*Animals are prone to recurrent infections, mainly from the respiratory and gastrointestinal tract
**E.g. pyrexia, [[Intestine Diarrhoea - Pathology|diarrhoea]], gingivitis and arthritis
**E.g. pyrexia, [[Diarrhoea|diarrhoea]], gingivitis and arthritis
*Puppies can be distinguished from other litter mates by the diluted grey colouring
*Puppies can be distinguished from other litter mates by the diluted grey colouring
*Affected puppies show symptoms such as fever, joint pain and eye, skin and respiratory infections from 8 weeks of age
*Affected puppies show symptoms such as fever, joint pain and eye, skin and respiratory infections from 8 weeks of age