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Created page with '*this results from inadequate liver function *occurs even though the liver has a large functional reserve and a …'
*this results from inadequate [[Liver - Anatomy & Physiology|liver]] function
*occurs even though the [[Liver - Anatomy & Physiology|liver]] has a large functional reserve and a high regenerative capacity
===Causes===
*low liver mass
**the functional reserve is depleted
NB: [[Liver - Anatomy & Physiology|liver]] enzyme levels in blood may not be markedly raised in chronic ongoing [[Liver - Anatomy & Physiology|liver]] damage because there may be few [[Liver - Anatomy & Physiology|liver]] cells remaining to leak enyzmes
*remodelling of the vascular and connective components after damage
**this may lead to inadequate nutritional supply to the hepatocytes, thus reducing their function
*impaired function of one specific or many of its diverse functions
**eg failure of detoxification
***aldosterone - a failure of its proper inactivation results in hypervolaemia since a feature of this hormone is to cause sodium and hence water rentention
****this is a factor in the development of ascites
***oestrogen - a failure of its proper inactivation will result in an accumulation of this hormone with atrophy of the genitals and an enlargement of the breasts in the male
***plant pigments - failure to detoxify will lead to their accumulation in the tissues and photosenistisation may result if they are photodynamic
**eg metabolic upset
***the failing [[Liver - Anatomy & Physiology|liver]] is unable to convert ammonia to urea, resulting in a rise in the level of blood ammonia
***lowered level of plasma albumin contributes to the development of ascites
[[Category:Liver - General Pathology]]
*occurs even though the [[Liver - Anatomy & Physiology|liver]] has a large functional reserve and a high regenerative capacity
===Causes===
*low liver mass
**the functional reserve is depleted
NB: [[Liver - Anatomy & Physiology|liver]] enzyme levels in blood may not be markedly raised in chronic ongoing [[Liver - Anatomy & Physiology|liver]] damage because there may be few [[Liver - Anatomy & Physiology|liver]] cells remaining to leak enyzmes
*remodelling of the vascular and connective components after damage
**this may lead to inadequate nutritional supply to the hepatocytes, thus reducing their function
*impaired function of one specific or many of its diverse functions
**eg failure of detoxification
***aldosterone - a failure of its proper inactivation results in hypervolaemia since a feature of this hormone is to cause sodium and hence water rentention
****this is a factor in the development of ascites
***oestrogen - a failure of its proper inactivation will result in an accumulation of this hormone with atrophy of the genitals and an enlargement of the breasts in the male
***plant pigments - failure to detoxify will lead to their accumulation in the tissues and photosenistisation may result if they are photodynamic
**eg metabolic upset
***the failing [[Liver - Anatomy & Physiology|liver]] is unable to convert ammonia to urea, resulting in a rise in the level of blood ammonia
***lowered level of plasma albumin contributes to the development of ascites
[[Category:Liver - General Pathology]]