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==[[Liver Failure]]==
==[[Liver Failure]]==
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===Syndromes in liver failure===
[[Icterus]]
[[Icterus]]
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===Syndromes in liver failure===
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[[Photosensitisation]]
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====[[Photosensitisation]]====
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[[Hepatic Encephalopathy]]
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====Hepatic Encephalopathy====
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=====Clinical=====
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*non-specific neurological signs (attributed to the retention of ammonia and gamma aminobutyric acid in [[Liver - Anatomy & Physiology|liver]] failure and their effects on the brain)
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**dullness
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**apparent unawareness of surroundings
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**pointless or compulsive movements
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**mania
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**generalised convulsions
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NB: usually soon followed by death
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=====Microscopically=====
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*lesions in the brain vary in expression
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**most species may show myelin degeneration consisting of vacuoles between the grey and white matter
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**the horse may show very little visible neural changes, perhaps an increase in astrocytes
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=====Causes=====
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::[[Liver Developmental - Pathology#Portosystemic shunt|Portosystemic Shunting]]
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::Chronic [[Liver - Anatomy & Physiology|liver]] damage
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*due to ingestion of toxic compounds over a long period of time
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*E.g. [[Liver Toxic - Pathology#ragwort|ragwort]]
====Bleeding Tendencies====
====Bleeding Tendencies====