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Created page with '===Fibrosis - Repair=== *any hepatic injury of consequence is going to cause a degree of fibrosis when the lesion has resolved *the fibrosis comes from the proliferation of the …'
===Fibrosis - Repair===
*any hepatic injury of consequence is going to cause a degree of fibrosis when the lesion has resolved
*the fibrosis comes from the proliferation of the supportive connective tissue in the [[Liver - Anatomy & Physiology|liver]]
*fibrosis isolates the [[Liver - Anatomy & Physiology|liver]] cells by effectively changing the sinusoids into capillaries
*when a certain amount of fibrosis occurs, it can be self-perpetuating
**the end result is a small scarred [[Liver - Anatomy & Physiology|liver]] with functional failure
====Histological patterns====
=====Periacinar fibrosis=====
*the fibrosis surrounds the hepatic venule (centrilobular vein)
*can be seen when there is chronic passive congestion with atrophy of the surrounding periacinar hepatocytes and condensation of the remaining connective tissue
=====Biliary fibrosis=====
*accompanying inflammation centered on the portal triads
=====Post necrotic scarring=====
*following massive necrosis where the necrotic cells are removed and the defect is reapired by fibrosis
*seen as bands of fibrous tissue
=====Diffuse fibrosis=====
*resulting from repeated damage to one or more zones
*the fibrosis generated proliferates throughout to involve all the tissue
[[Category:Liver_-_General_Pathology]]
*any hepatic injury of consequence is going to cause a degree of fibrosis when the lesion has resolved
*the fibrosis comes from the proliferation of the supportive connective tissue in the [[Liver - Anatomy & Physiology|liver]]
*fibrosis isolates the [[Liver - Anatomy & Physiology|liver]] cells by effectively changing the sinusoids into capillaries
*when a certain amount of fibrosis occurs, it can be self-perpetuating
**the end result is a small scarred [[Liver - Anatomy & Physiology|liver]] with functional failure
====Histological patterns====
=====Periacinar fibrosis=====
*the fibrosis surrounds the hepatic venule (centrilobular vein)
*can be seen when there is chronic passive congestion with atrophy of the surrounding periacinar hepatocytes and condensation of the remaining connective tissue
=====Biliary fibrosis=====
*accompanying inflammation centered on the portal triads
=====Post necrotic scarring=====
*following massive necrosis where the necrotic cells are removed and the defect is reapired by fibrosis
*seen as bands of fibrous tissue
=====Diffuse fibrosis=====
*resulting from repeated damage to one or more zones
*the fibrosis generated proliferates throughout to involve all the tissue
[[Category:Liver_-_General_Pathology]]