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*Phenothiazine which was used as an anthelmintic
*Phenothiazine which was used as an anthelmintic
*Tetracycline - if one injects bitches with tetracycline when pregnant, puppies are born with brown [[Oral Cavity - Teeth & Gingiva - Anatomy & Physiology|teeth]], which fluoresce under UV light.
*Tetracycline - if one injects bitches with tetracycline when pregnant, puppies are born with brown [[Oral Cavity - Teeth & Gingiva - Anatomy & Physiology|teeth]], which fluoresce under UV light.
*Haemosiderin may also produce pinky / brown colour to [[Oral Cavity - Teeth & Gingiva - Anatomy & Physiology|teeth]] usually due to damage and haemorrhage into [[Oral Cavity - Teeth & Gingiva - Anatomy & Physiology|tooth]].[[Category:Teeth_-_Developmental_Pathology]]
*Haemosiderin may also produce pinky / brown colour to [[Oral Cavity - Teeth & Gingiva - Anatomy & Physiology|teeth]] usually due to damage and haemorrhage into [[Oral Cavity - Teeth & Gingiva - Anatomy & Physiology|tooth]].
*'''Primary'''
**Ingestion of photodynamic substance from plants (''Hypericum perforatum'' and ''Fagopyrum sagittatum'' - buckwheat) or fungal contaminants
**Induced by drug administration - phenothiazines, tetracyclines, thiazides, sulphonamides
*'''Abnormal porphyrin metabolism'''
**Bovine congenital porphyria
**Bovine erythropoeitic protoporphyria
*'''Hepatogenous'''
**Impaired excretion of phylloerythrin (chlorophyl metabolism product) due to hepatic disease
**[[Liver Biliary Tract - Pathology#Obstruction|Biliary obstruction]]
**Inherited defects
**Hepatic injury due to toxic plants or fungal contaminants, chemicals or some infectious agents
*Grossly:
**In areas lacking hair or pigment
**Erythema, oedema -> blisters, exudation, necrosis, sloughing or keratitis
*Microscopically:
**Subepidermal vesicles
**Ulceration
**Secondary infection
[[Category:Teeth_-_Developmental_Pathology]]
[[Category:Liver_-_General_Pathology]]
[[Category:Liver_-_General_Pathology]]