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Hepatic Microvascular Dysplasia (view source)
Revision as of 12:06, 7 June 2010
, 12:06, 7 June 2010Created page with '*Small intrahepatic portal vessels and portal endothelial hyperplasia which allows abnormal communication between portal and systemic circulation. *Can develop as a separate enti…'
*Small intrahepatic portal vessels and portal endothelial hyperplasia which allows abnormal communication between portal and systemic circulation.
*Can develop as a separate entity or in conjunction with a portosystemic shunt.
*Can cause c/s similar to those of PSS.
*[[Control of Feeding - Anatomy & Physiology#The Vomit Reflex|Vomiting]], [[Diarrhoea|diarrhoea]], [[Urinary System - Anatomy & Physiology|urinary tract]] changes associated with ammonium biurate urolithiasis, stunted growth, prolonged recovery from anesthesia.
*Average age of presentation =3yrs.
*Mainly small dogs, esp. Yorkies
*Females>males
===Histology===
**Arteriolarization of central veins
**smooth muscle proliferation (segmental) within the walls of central veins
**random distribution of small calibre vessels
**endothelial hyperplasia within portal triads
**dilation of periacinar vascular spaces.
**May also see decreased diameter of intrahepatic veins.
*Can’t be accurately distinguished from PSS alone.
*Seen in older dogs than PSS
*Higher MCV, serum postprandial bile acid concentrations, serum albumin and cholesterol concentrations when PSS and HMD together, compared to HMD alone.
[[Category:Liver_-_Developmental_Pathology]]
*Can develop as a separate entity or in conjunction with a portosystemic shunt.
*Can cause c/s similar to those of PSS.
*[[Control of Feeding - Anatomy & Physiology#The Vomit Reflex|Vomiting]], [[Diarrhoea|diarrhoea]], [[Urinary System - Anatomy & Physiology|urinary tract]] changes associated with ammonium biurate urolithiasis, stunted growth, prolonged recovery from anesthesia.
*Average age of presentation =3yrs.
*Mainly small dogs, esp. Yorkies
*Females>males
===Histology===
**Arteriolarization of central veins
**smooth muscle proliferation (segmental) within the walls of central veins
**random distribution of small calibre vessels
**endothelial hyperplasia within portal triads
**dilation of periacinar vascular spaces.
**May also see decreased diameter of intrahepatic veins.
*Can’t be accurately distinguished from PSS alone.
*Seen in older dogs than PSS
*Higher MCV, serum postprandial bile acid concentrations, serum albumin and cholesterol concentrations when PSS and HMD together, compared to HMD alone.
[[Category:Liver_-_Developmental_Pathology]]