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Portal Hypertension, Idiopathic Noncirrhotic (view source)
Revision as of 12:07, 7 June 2010
, 12:07, 7 June 2010Created page with 'JAVMA paper *Portal hypertension *Sustained impairment of forward venous flow anywhere along the path from the portal vein to the right side of the heart. *Luminal (thrombosis,…'
JAVMA paper
*Portal hypertension
*Sustained impairment of forward venous flow anywhere along the path from the portal vein to the right side of the heart.
*Luminal (thrombosis, parasites) or extraluminal obstruction (hepatic fibrosis or nodular regeneration) or relative restriction of flow due to massive portal volume overload (arterioportal fistulas).
*Hepatomegaly associated with posthepatic obstruction
*Microhepatica – associated with prehepatic/hepatic causes.
*Hepatic encephalopathy and GI bleeding not associated with posthepatic causes.
*Most common causes are RHS heart failure and severe diffuse hepatobiliary disease that results in cirrhosis.
===Histology===
*indistinguishable from microvascular dysplasia or surgically created portosystemic shunts
**Portal triad arteriole proliferation
**portal veins small to large
**variable portal triad fibrosis
**hepatic lobule size variation
**arterioles scattered throughout hepatic parenchyma
**portal veins – small
**expanded perivenular connective tissue by arterioles and distended lymphatics.
[[Category:Liver_-_Developmental_Pathology]]
*Portal hypertension
*Sustained impairment of forward venous flow anywhere along the path from the portal vein to the right side of the heart.
*Luminal (thrombosis, parasites) or extraluminal obstruction (hepatic fibrosis or nodular regeneration) or relative restriction of flow due to massive portal volume overload (arterioportal fistulas).
*Hepatomegaly associated with posthepatic obstruction
*Microhepatica – associated with prehepatic/hepatic causes.
*Hepatic encephalopathy and GI bleeding not associated with posthepatic causes.
*Most common causes are RHS heart failure and severe diffuse hepatobiliary disease that results in cirrhosis.
===Histology===
*indistinguishable from microvascular dysplasia or surgically created portosystemic shunts
**Portal triad arteriole proliferation
**portal veins small to large
**variable portal triad fibrosis
**hepatic lobule size variation
**arterioles scattered throughout hepatic parenchyma
**portal veins – small
**expanded perivenular connective tissue by arterioles and distended lymphatics.
[[Category:Liver_-_Developmental_Pathology]]