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==[[Lysosomal Storage Disease]]==
==[[Lysosomal Storage Disease]]==
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==Amyloidosis==
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==[[Amyloidosis]]==
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*amyloid infiltration occurs in all species
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*an inert substance deposited under the endothelium and basement membranes of a variety of tissues
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**renal glomeruli
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**[[Pancreas - Anatomy & Physiology#Endocrine|Islets of Langerhans]] in the [[Pancreas - Anatomy & Physiology|pancreas]]
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**[[Liver - Anatomy & Physiology|liver]] (between the sinusoidal reticulum and the hepatic cords)
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====Causes====
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May be a primary condition or appear secondary to some chronic tissue destructive process
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*an infectious process elsewhere in the body
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*a result of sustained antigenic stimulation, eg repeated injections with an antigenic substance or production of excessive antibody by leukocytes
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====Gross====
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*pale (greyish waxy appearance)
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*enlarged
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*rounded edges
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*firm
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*very prone to rupture
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====Microscopically====
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*deposition of amyloid in the space of Disse
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*shows 'apple-green' fluorescence under polarised light after staining with Congo Red
[[Category:Liver_-_Pathology]]
[[Category:Liver_-_Pathology]]