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Created page with '*adenovirus - Canine Adenovirus 1 *also known as Rubarth's Disease, Canine adenovirus infection *acute and generalised infection *young dogs *highly infectious *spread via th…'
*adenovirus - [[Canine Adenovirus 1]]
*also known as Rubarth's Disease, Canine adenovirus infection
*acute and generalised infection
*young dogs
*highly infectious
*spread via the urine of infected animals over a long period of time
=====Clinical=====
*[[Lymph Nodes - Anatomy & Physiology|lymph nodes]] and [[Tonsils - Anatomy & Physiology|tonsils]] are enlarged and reddened, sometimes haemorrhagic
*recovering animals may show an immune-mediated uveitis with corneal opacity
=====Gross=====
*the virus has a tropism for endothelium and hepatocytes
**widespread haemorrhages, especially on serosal surface
*distinctly pale mottled appearance
**from extensive necrosis, characteristically periacinar (centrilobular) in distribution - the reason for the increased susceptibility of this area is not known
*enlarged
*friable
*fibrinous or fibrino-haemorrhagic strands between lobes
*[[Gall Bladder - Anatomy & Physiology|gall bladder]]
**wall usually shows oedema (up to 2cm diameter)
=====Microscopically=====
*basophilic intranuclear inclusion bodies
**in hepatocytes and macrophages
[[Category:Liver_-_Inflammatory_Pathology]][[Category:Dog]]
*also known as Rubarth's Disease, Canine adenovirus infection
*acute and generalised infection
*young dogs
*highly infectious
*spread via the urine of infected animals over a long period of time
=====Clinical=====
*[[Lymph Nodes - Anatomy & Physiology|lymph nodes]] and [[Tonsils - Anatomy & Physiology|tonsils]] are enlarged and reddened, sometimes haemorrhagic
*recovering animals may show an immune-mediated uveitis with corneal opacity
=====Gross=====
*the virus has a tropism for endothelium and hepatocytes
**widespread haemorrhages, especially on serosal surface
*distinctly pale mottled appearance
**from extensive necrosis, characteristically periacinar (centrilobular) in distribution - the reason for the increased susceptibility of this area is not known
*enlarged
*friable
*fibrinous or fibrino-haemorrhagic strands between lobes
*[[Gall Bladder - Anatomy & Physiology|gall bladder]]
**wall usually shows oedema (up to 2cm diameter)
=====Microscopically=====
*basophilic intranuclear inclusion bodies
**in hepatocytes and macrophages
[[Category:Liver_-_Inflammatory_Pathology]][[Category:Dog]]