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| − | == Lobular dissecting hepatitis == | + | == [[Lobular Dissecting Hepatitis]] == |
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| − | *Rare cause of chronic [[Liver - Anatomy & Physiology|liver]] failure in young dogs
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| − | *Less than 5yrs of age
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| − | *Standard poodle overrepresented
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| − | *Gross findings:
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| − | **Micronodular microhepatica, ascites, numerous portosystemic shunts
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| − | *Histology:
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| − | **Hepatic architecture disrupted by collagen and reticulin fibres separating the hepatic lobules into small clusters and individual cells
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| − | **Hepatocytes mutlifocally swollen, lightly eosinophilic, some binucleated.
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| − | **Variable nodular regeneration.
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| − | **Scattered necrotic cells and occasional foci of inflammation.
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| − | *Cu2+ accumulation not a consistent finding.
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| − | *Aetiology – possibly a specific reaction pattern in neonatal/juvenile [[Liver - Anatomy & Physiology|liver]] .
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| − | *Differentials:
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| − | **Copper toxicity
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| − | **Copper storage disease
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| − | **Aflatoxin
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| − | **Infectious diseases such as Leptospria spp. and CAV-1.
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| | == Hepatitis in cats == | | == Hepatitis in cats == |