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* Long dosage regimens of Sulphonamides have resulted in keratoconjunctivitis sicca/'dry eye' in dogs.
 
* Long dosage regimens of Sulphonamides have resulted in keratoconjunctivitis sicca/'dry eye' in dogs.
 
* Sulphonamides inhibit thyroid gland function and so mild signs of hypothyroidism have been seen in dogs that have had intesive dosage regimens.
 
* Sulphonamides inhibit thyroid gland function and so mild signs of hypothyroidism have been seen in dogs that have had intesive dosage regimens.
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===Hepatotoxixity===
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*some of these casue hepatic necrosis in susceptible animals
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*has been associated with a reduced capability of detoxifying the metabolites
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*Doberman Pincher breed appear to be susceptible
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[[Category:Hepatotoxicity,_Drug_induced]]
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