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Created page with '[http://w3.vet.cornell.edu/nst/nst.asp?Fun=Image&imgID=7762 Image of pancreatic garstrinoma in a dog from Cornell Veterinary Medicine] *Described in dogs, cats *Known as Zollinge…'
[http://w3.vet.cornell.edu/nst/nst.asp?Fun=Image&imgID=7762 Image of pancreatic garstrinoma in a dog from Cornell Veterinary Medicine]
*Described in dogs, cats
*Known as Zollinger-Ellison syndrome in humans
*Uncommon compared to beta cell neoplasms
*Excess gastrin causes hyperacidity in the stomach and mucosal hyperplasia of the antral region causing gastric and [[Duodenum - Anatomy & Physiology|duodenal]] ulceration
====Clinical signs====
*Anorexia
*Severe weight loss
*[[Control of Feeding - Anatomy & Physiology#The Vomit Reflex|Vomiting]]
*[[Diarrhoea]]
*Dehydration
====Pathology====
*Multiple variably sized neoplasms
*Increased connective tissue mass - firm
*Partiallty encapsulated
*Invade locally
*Metastases to [[Liver - Anatomy & Physiology|liver]] and local lymph nodes are common
[[Category:Pancreas_-_Hyperplastic_and_Neoplastic_Pathology]][[Category:Endocrine_System_-_Pathology]][[Category:Dog]][[Category:Cat]]
*Described in dogs, cats
*Known as Zollinger-Ellison syndrome in humans
*Uncommon compared to beta cell neoplasms
*Excess gastrin causes hyperacidity in the stomach and mucosal hyperplasia of the antral region causing gastric and [[Duodenum - Anatomy & Physiology|duodenal]] ulceration
====Clinical signs====
*Anorexia
*Severe weight loss
*[[Control of Feeding - Anatomy & Physiology#The Vomit Reflex|Vomiting]]
*[[Diarrhoea]]
*Dehydration
====Pathology====
*Multiple variably sized neoplasms
*Increased connective tissue mass - firm
*Partiallty encapsulated
*Invade locally
*Metastases to [[Liver - Anatomy & Physiology|liver]] and local lymph nodes are common
[[Category:Pancreas_-_Hyperplastic_and_Neoplastic_Pathology]][[Category:Endocrine_System_-_Pathology]][[Category:Dog]][[Category:Cat]]