Changes

**Organisms can be killed using radiation or chemicals so that they still possess the [[Adaptive Immune System - WikiBlood#Antigen Recognition|antigens]] to stimulate an immune response, but the organisms are unable to replicate inside the host

**Organisms can be killed using radiation or chemicals so that they still possess the [[Adaptive Immune System - WikiBlood#Antigen Recognition|antigens]] to stimulate an immune response, but the organisms are unable to replicate inside the host

**Toxins are inactivated to produce a toxoid which will still have the [[Adaptive Immune System - WikiBlood#Antigen Recognition|antigens]] needed to produce an immune response but will not be harmful to the host

**Toxins are inactivated to produce a toxoid which will still have the [[Adaptive Immune System - WikiBlood#Antigen Recognition|antigens]] needed to produce an immune response but will not be harmful to the host

**Needs two doses (for an explanation on the [[Lymphocytes - WikiBlood#T cells|T cell]] response click [[B cell differentiation - WikiBlood#T-Cell Dependent and Independent Responses|here]])

**Needs two doses (for an explanation on the [[Lymphocytes#T cells|T cell]] response click [[B cell differentiation - WikiBlood#T-Cell Dependent and Independent Responses|here]])

**1:4000 formaldehyde is the current preparation  

**1:4000 formaldehyde is the current preparation  

**Inactivants containing azuridines and beta propiolactone are being developed which do not leave a persistent infectious viral fraction (like formaldehyde)

**Inactivants containing azuridines and beta propiolactone are being developed which do not leave a persistent infectious viral fraction (like formaldehyde)

*Some stimulate the immune system to amplify the adaptive immune response to [[Adaptive Immune System - WikiBlood#Antigen Recognition|antigens]]

*Some stimulate the immune system to amplify the adaptive immune response to [[Adaptive Immune System - WikiBlood#Antigen Recognition|antigens]]

**E.g. Pathogen-associated molecular patterns (PAMPs)  

**E.g. Pathogen-associated molecular patterns (PAMPs)  

**E.g. PAMP-like adjuvants which assist naive [[Lymphocytes - WikiBlood#T cells|T cell]] priming

**E.g. PAMP-like adjuvants which assist naive [[Lymphocytes#T cells|T cell]] priming

*Different subtypes of [[Lymphocytes - WikiBlood#Helper CD4+|T helper cells]] are stimulated by different adjuvants

*Different subtypes of [[Lymphocytes#Helper CD4+|T helper cells]] are stimulated by different adjuvants

**E.g. Aluminium salts generate bias [[T cell differentiation - WikiBlood#TH2 Cells|T helper II]] responses for [[Immunoglobulins - WikiBlood|'''antibody''']]-mediated immunity

**E.g. Aluminium salts generate bias [[T cell differentiation - WikiBlood#TH2 Cells|T helper II]] responses for [[Immunoglobulins - WikiBlood|'''antibody''']]-mediated immunity

**E.g. Killed mycobacteria generate IL-12 producing good '''cell'''-mediated immunity

**E.g. Killed mycobacteria generate IL-12 producing good '''cell'''-mediated immunity

*Immunity for the extracellular phase requires neutralising [[Immunoglobulins - WikiBlood|'''antibody''']]

*Immunity for the extracellular phase requires neutralising [[Immunoglobulins - WikiBlood|'''antibody''']]

**[[Lymphocytes - WikiBlood#B Cells|B cells]] needed

**[[Lymphocytes#B Cells|B cells]] needed

**[[T cell differentiation - WikiBlood#TH2 Cells|T helper type II cells]] needed (for the [[MHC - WikiBlood#MHC II|MHC class II pathway]])

**[[T cell differentiation - WikiBlood#TH2 Cells|T helper type II cells]] needed (for the [[MHC - WikiBlood#MHC II|MHC class II pathway]])

**Live vaccine can be used

**Live vaccine can be used

**Subunit vaccine can be used

**Subunit vaccine can be used

*Immunity for the intracellular phase requires [[Lymphocytes - WikiBlood#Cytotoxic CD8+|'''CD8+ cytotoxic T cells''']]

*Immunity for the intracellular phase requires [[Lymphocytes#Cytotoxic CD8+|'''CD8+ cytotoxic T cells''']]

**[[MHC - WikiBlood#MHC I|MHC class I pathway]]

**[[MHC - WikiBlood#MHC I|MHC class I pathway]]

**Only live vaccine can be used to get into cells (entering via the endogenous pathway)

**Only live vaccine can be used to get into cells (entering via the endogenous pathway)

*Extracellular bacterial infection needs [[Immunoglobulins - WikiBlood|'''antibody''']] production for [[Complement - WikiBlood#Opsonisation|opsonisation]] and to activate the [[Complement - WikiBlood|complement pathways]]

*Extracellular bacterial infection needs [[Immunoglobulins - WikiBlood|'''antibody''']] production for [[Complement - WikiBlood#Opsonisation|opsonisation]] and to activate the [[Complement - WikiBlood|complement pathways]]

**[[Lymphocytes - WikiBlood#B Cells|B cells]] needed

**[[Lymphocytes#B Cells|B cells]] needed

**[[T cell differentiation - WikiBlood#TH2 Cells|T helper type II cells]] needed

**[[T cell differentiation - WikiBlood#TH2 Cells|T helper type II cells]] needed