Changes

**Gene codes for a DNA repair enzyme involved in V(D)J recombination for antigen receptors of [[Lymphocytes|lymphocytes]] (e.g. Ig and TCR)

**Gene codes for a DNA repair enzyme involved in V(D)J recombination for antigen receptors of [[Lymphocytes|lymphocytes]] (e.g. Ig and TCR)

*No functional [[Lymphocytes#B cells|B cells]] or [[Lymphocytes#T cells|T cells]]  

*No functional [[Lymphocytes#B cells|B cells]] or [[Lymphocytes#T cells|T cells]]  

*Foals develop infections (usually around 8 weeks of age as maternal [[Immunoglobulins - WikiBlood|antibody]] in [[Materno-fetal immunity - WikiBlood#Passive transfer via colostrum|colostrum]] wanes around this time)

*Foals develop infections (usually around 8 weeks of age as maternal [[Immunoglobulins|antibody]] in [[Materno-fetal immunity - WikiBlood#Passive transfer via colostrum|colostrum]] wanes around this time)

*Foals usually die from bronchopneumonia

*Foals usually die from bronchopneumonia

**IL-2 receptor is a receptor for the cytokine IL-2 which causes [[Lymphocytes#T cells|T cells]] to proliferate

**IL-2 receptor is a receptor for the cytokine IL-2 which causes [[Lymphocytes#T cells|T cells]] to proliferate

*Causes lymphoid hypoplasia, stunted growth and increases the animal's susceptibility to infection

*Causes lymphoid hypoplasia, stunted growth and increases the animal's susceptibility to infection

*Animal usually dies from pneumonia or sepsis as the level of maternal [[Immunoglobulins - WikiBlood|antibody]] decreases

*Animal usually dies from pneumonia or sepsis as the level of maternal [[Immunoglobulins|antibody]] decreases

====Selective [[IgA]] deficiency of German Shepherd Dogs====

====Selective [[IgA]] deficiency of German Shepherd Dogs====