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**Causes lymphoid exhaustion
**Causes lymphoid exhaustion
**Associated with plasma cell hypertrophy and hypergammaglobulinaemia
**Associated with plasma cell hypertrophy and hypergammaglobulinaemia
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***Due to an increase in [[Immunoglobulin M - WikiBlood|IgM]]
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***Due to an increase in [[Immunoglobulin M|IgM]]
**With infections of increased duration, the [[Lymph Nodes - Anatomy & Physiology|lymph nodes]] and [[Spleen - Anatomy & Physiology|spleen]] shrink due to exhaustion of their cellular elements
**With infections of increased duration, the [[Lymph Nodes - Anatomy & Physiology|lymph nodes]] and [[Spleen - Anatomy & Physiology|spleen]] shrink due to exhaustion of their cellular elements