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Created page with '{{review}} <p>''Shortened to IgE''</p> thumb|150px|right|'''IgE''' thumb|right|150px|IgE - B. Catchpole, RVC 2008 <p>Unlike IgM, IgG and [[…'
{{review}}
<p>''Shortened to IgE''</p>
[[Image:LH IgE.png|thumb|150px|right|'''IgE''']]
[[Image:IgE.jpg|thumb|right|150px|IgE - B. Catchpole, RVC 2008]]
<p>Unlike IgM, IgG and [[IgA]], IgE does not function as a soluble antibody and is found in low levels in blood plasma. Like [[IgA]] it is produced by plasma cells and is mainly localised to mucosal surfaces.</p>
==Structure==
<p>IgE is Y-shaped with heavy chain type ε, and exists as a monomer.</p>
''Note: Janeway <ref>{{citation|initiallast = Janeway|initialfirst = C.A|2last = Travers|2first = P|3last = Walport|3first = M|finallast = Shlomchik|finalfirst = M.J|year = 2005|title = Immunobiology: The immune system in health and disease|ed = 6th |city = New York|pub = Garland Science Publishing|range = 156-157}}</ref> states that IgE has no hinge region whereas Tizard <ref>{{citation|initiallast = Tizard|initialfirst = I.R|year = 2004|title = Veterinary Immunology: An Introduction|ed = 7th|city = Philadelphia|pub = Saunders|range = 148-149}}</ref> indicates that it does.
==Production==
<p>It is produced when Th2 cells stimulate CD40 and produce Il-4 and Il-13 which causes B cell differentiation to plasma cells and class switching to IgE production.</p>
==Function==
<p>
*IgE triggers acute inflammation by binding to the FCεRI receptors on mast cells in the lamina propria and basophils, causing degranulation
*It is involved in type I hypersensitivity reactions
*Cross-linking of IgE molecules by antigen triggers mast cell degranulation and an inflammatory response</p>
<p>
*IgE has considerable involvement in producing immunity to parasitic worms and particularly nematode parasites
**It may mediate their expulsion or killing via mast cell activity, cytotoxic eosinophils, macrophages, and so on</p>
==References==
<references />
<br>
----
<center><b><sup>[[Immunoglobulins|Immunoglobulins]]: [[Immunoglobulin A|Immunoglobulin A]], [[Immunoglobulin D|Immunoglobulin D]], [[Immunoglobulin E - WikiBlood|Immunoglobulin E]], [[Immunoglobulin G|Immunoglobulin G]] & [[Immunoglobulin M|Immunoglobulin M]]</sup></b></center>
<p>''Shortened to IgE''</p>
[[Image:LH IgE.png|thumb|150px|right|'''IgE''']]
[[Image:IgE.jpg|thumb|right|150px|IgE - B. Catchpole, RVC 2008]]
<p>Unlike IgM, IgG and [[IgA]], IgE does not function as a soluble antibody and is found in low levels in blood plasma. Like [[IgA]] it is produced by plasma cells and is mainly localised to mucosal surfaces.</p>
==Structure==
<p>IgE is Y-shaped with heavy chain type ε, and exists as a monomer.</p>
''Note: Janeway <ref>{{citation|initiallast = Janeway|initialfirst = C.A|2last = Travers|2first = P|3last = Walport|3first = M|finallast = Shlomchik|finalfirst = M.J|year = 2005|title = Immunobiology: The immune system in health and disease|ed = 6th |city = New York|pub = Garland Science Publishing|range = 156-157}}</ref> states that IgE has no hinge region whereas Tizard <ref>{{citation|initiallast = Tizard|initialfirst = I.R|year = 2004|title = Veterinary Immunology: An Introduction|ed = 7th|city = Philadelphia|pub = Saunders|range = 148-149}}</ref> indicates that it does.
==Production==
<p>It is produced when Th2 cells stimulate CD40 and produce Il-4 and Il-13 which causes B cell differentiation to plasma cells and class switching to IgE production.</p>
==Function==
<p>
*IgE triggers acute inflammation by binding to the FCεRI receptors on mast cells in the lamina propria and basophils, causing degranulation
*It is involved in type I hypersensitivity reactions
*Cross-linking of IgE molecules by antigen triggers mast cell degranulation and an inflammatory response</p>
<p>
*IgE has considerable involvement in producing immunity to parasitic worms and particularly nematode parasites
**It may mediate their expulsion or killing via mast cell activity, cytotoxic eosinophils, macrophages, and so on</p>
==References==
<references />
<br>
----
<center><b><sup>[[Immunoglobulins|Immunoglobulins]]: [[Immunoglobulin A|Immunoglobulin A]], [[Immunoglobulin D|Immunoglobulin D]], [[Immunoglobulin E - WikiBlood|Immunoglobulin E]], [[Immunoglobulin G|Immunoglobulin G]] & [[Immunoglobulin M|Immunoglobulin M]]</sup></b></center>