Changes

==Introduction==

==Introduction==

* Also known as [[Immunoglobulin E - WikiBlood|IgE]]-mediated or anaphylactic hypersensitivity.

* Also known as [[Immunoglobulin E|IgE]]-mediated or anaphylactic hypersensitivity.

* Ranges from mild cases, such as hayfever, to life-threatening reactions, such as bee-stings.  

* Ranges from mild cases, such as hayfever, to life-threatening reactions, such as bee-stings.  

* Antigens that induce a type I reaction are known as allergens.

* Antigens that induce a type I reaction are known as allergens.

* Generally affects face, eyes, nose and feet

* Generally affects face, eyes, nose and feet

* [[Immunoglobulin E - WikiBlood|IgE]] has a high affinity to IgE receptors on [[Mast Cells|mast cells]] and [[Basophils|basophils]], and so binds these receptors.

* [[Immunoglobulin E|IgE]] has a high affinity to IgE receptors on [[Mast Cells|mast cells]] and [[Basophils|basophils]], and so binds these receptors.

==Common allergens which elict a type I hypersensitivity reaction:==

==Common allergens which elict a type I hypersensitivity reaction:==

'''2. Subsequent exposure to the specific allergen (Image 2):'''

'''2. Subsequent exposure to the specific allergen (Image 2):'''

* [[Mast Cells|Mast cells]] degranulate.

* [[Mast Cells|Mast cells]] degranulate.

* [[Basophils|Basophils]] with [[Immunoglobulin E - WikiBlood|IgE]] receptors are recruited and also degranulate.

* [[Basophils|Basophils]] with [[Immunoglobulin E|IgE]] receptors are recruited and also degranulate.