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*IgA in alimentary system is produced by plasma cells in the lamina propria
*IgA in alimentary system is produced by plasma cells in the lamina propria
**It is the only Ig that can cross into the lumen of the alimentary tract
**It is the only Ig that can cross into the lumen of the alimentary tract
−
During lactation the levels of IgA increase so that it becomes the predominant immunoglobulin in the milk (more than IgG). Mucosal epithelium have a “poly Ig receptor” and this bind to the J chain on the IgA and allows IgA to travel across the cell. IgA crosses the cell in a transport vesicle and is released by exocytosis.</p>
+
During lactation the levels of IgA increase so that it becomes the predominant immunoglobulin in the milk (more than [[IgG]]). Mucosal epithelium have a “poly Ig receptor” and this bind to the J chain on the IgA and allows IgA to travel across the cell. IgA crosses the cell in a transport vesicle and is released by exocytosis.</p>
==Function==
==Function==
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*IgA is a "non-inflammatory" isotype as it does not does not activate [[Complement|complement]] by the classical pathway and has no role in opsonisation
*IgA is a "non-inflammatory" isotype as it does not does not activate [[Complement|complement]] by the classical pathway and has no role in opsonisation
**This helps to preserve the mucosal integrity and function
**This helps to preserve the mucosal integrity and function
−
*Ruminant mucosal IgG subclass similarly is also a poor [[Complement|complement]] activator.</p>
+
*Ruminant mucosal [[IgG]] subclass similarly is also a poor [[Complement|complement]] activator.</p>
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<center><b><sup>[[Immunoglobulins|Immunoglobulins]]: [[Immunoglobulin A|Immunoglobulin A]], [[Immunoglobulin D|Immunoglobulin D]], [[Immunoglobulin E|Immunoglobulin E]], [[Immunoglobulin G|Immunoglobulin G]] & [[Immunoglobulin M|Immunoglobulin M]]</sup></b></center>
<center><b><sup>[[Immunoglobulins|Immunoglobulins]]: [[Immunoglobulin A|Immunoglobulin A]], [[Immunoglobulin D|Immunoglobulin D]], [[Immunoglobulin E|Immunoglobulin E]], [[Immunoglobulin G|Immunoglobulin G]] & [[Immunoglobulin M|Immunoglobulin M]]</sup></b></center>