Changes

<p> The parenchyma is supported by a fine mesh of reticular fibres and is divided into two types of tissue, the red and the white pulp, which are separated by the marginal sinus.</p>

<p> The parenchyma is supported by a fine mesh of reticular fibres and is divided into two types of tissue, the red and the white pulp, which are separated by the marginal sinus.</p>

===Red Pulp===

===Red Pulp===

<p>The red pulp makes up the majority of the spleen and is composed of a network of cell cords in series with vascular sinuses. The splenic cords contain [[Macrophages|macrophages]], [[B cell differentiation - WikiBlood#Plasma cells|plasma cells]], [[Lymphocytes|lymphocytes]] and other mature blood cells e.g. [[Granulocyte - WikiBlood|granulocytes]] and [[Erythrocytes|erythrocytes]].  While the vascular sinuses are wide vascular channels lined with endothelial cells. Blood cells and fluid can pass into the splenic cords through fenestrations in the sinus walls. </p>

<p>The red pulp makes up the majority of the spleen and is composed of a network of cell cords in series with vascular sinuses. The splenic cords contain [[Macrophages|macrophages]], [[B cell differentiation - WikiBlood#Plasma cells|plasma cells]], [[Lymphocytes|lymphocytes]] and other mature blood cells e.g. [[Granulocytes|granulocytes]] and [[Erythrocytes|erythrocytes]].  While the vascular sinuses are wide vascular channels lined with endothelial cells. Blood cells and fluid can pass into the splenic cords through fenestrations in the sinus walls. </p>

===White Pulp===

===White Pulp===

<p>White pulp is organised in relation to the splenic arterioles and consists of discrete lymphoid tissue surrounding a central arteriole. There is a sheath of [[Lymphocytes#T cells|T cells]] directly around the arteriole, the periarteriolar lymphoid sheath (PALS), which is surrounded by a marginal sinus, and then a zone of [[Lymphocytes#B cells|B cells]] and [[Macrophages|macrophages]] (the marginal zone). B cell follicles are associated with the marginal zone and expand and develop germinal centres after antigen activation. The marginal sinuses are linked to the red pulp sinuses. </p><p>White pulp stains basophilic in a H&E stain</p>

<p>White pulp is organised in relation to the splenic arterioles and consists of discrete lymphoid tissue surrounding a central arteriole. There is a sheath of [[Lymphocytes#T cells|T cells]] directly around the arteriole, the periarteriolar lymphoid sheath (PALS), which is surrounded by a marginal sinus, and then a zone of [[Lymphocytes#B cells|B cells]] and [[Macrophages|macrophages]] (the marginal zone). B cell follicles are associated with the marginal zone and expand and develop germinal centres after antigen activation. The marginal sinuses are linked to the red pulp sinuses. </p><p>White pulp stains basophilic in a H&E stain</p>