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The final product or purine degradation is uric acid which, under normal circumstances, is excreted in the urine in a more water soluble form. Mammals (except primates) oxidise uric acid to allantoin using the copper-containing enzyme ''urate oxidase.''
The final product or purine degradation is uric acid which, under normal circumstances, is excreted in the urine in a more water soluble form. Mammals (except primates) oxidise uric acid to allantoin using the copper-containing enzyme ''urate oxidase.''
Hyperuricaemia occurs when the uric acid is not removed from the blood and converted to allantoin by the liver, a failure of any one of the steps in the metabolic pathway.
Hyperuricaemia occurs when the uric acid is not removed from the blood and converted to allantoin by the liver, a failure of any one of the steps in the metabolic pathway.
Urate calculi in other breeds are associated with [[Portosystemic Shunt|porto-systemic shunting]].
Urate calculi in other breeds are associated with [[Portosystemic Shunt|porto-systemic shunting]].
[[Category:Pericardial_Pathology]]
[[Category:Pericardial_Pathology]]
[[Category:Dog]]