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| − | ===Sheep pulmonary adenomatosis (SPA/ Jaagsiekte)=== | + | ===[[Sheep Pulmonary Adenomatosis]] (SPA/ Jaagsiekte)=== |
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| − | *Also called '''pulmonary carcinomatosis'''
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| − | *Infectious [[Bronchi and Bronchioles Inflammatory - Pathology#Infectious causes of bronchitis or bronchiolitis|bronchiolar]]-[[Lungs Inflammatory - Pathology#Infectious causes of pneumonia|alveolar]] carcinoma caused by a [[Retroviridae|retrovirus]]
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| − | *Commonest under intensive management systems which favour aerosol transmission and close contact of disease
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| − | *Behaves like chronic pneumonia
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| − | *Takes months to years to express itself clinically as coughing and exercise intolerance
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| − | *Gross pathology:
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| − | **Heavy lungs which fail to collapse
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| − | **The lesions progress from small firm grey/white nodular lesions to extensive confluent areas with replacement by neoplastic tissue
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| − | **Cut surface oozes fluid
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| − | **There is often coexistent infection present
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| − | **Occasional metastases to bronchial and mediastinal lymph nodes can occur
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| − | *Histopathology:
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| − | **Widespread proliferation of alveolar (Type 2) and terminal bronchiolar epithelium, lining the alveoli and lower airways
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| − | **Multiple neoplastic foci of cuboidal/columnar cells forming papillary projections into the lumen
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| − | **Metastases of the same in the bronchial and mediastinal lymph nodes
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| − | *There is no serological test, and diagnosis depends upon raising the animal by the hind limbs whereupon a clear fluid issues from the nose = "Wheelbarrow test"
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| − | *'''[[Jaagsiekte - Pathology|More information]]'''
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| | ===Carcinoids=== | | ===Carcinoids=== |