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====Control====
====Control====
*Cull clinically affected animals
*Cull clinically affected animals
*Also called '''pulmonary carcinomatosis'''
*Infectious [[Bronchi and Bronchioles Inflammatory - Pathology#Infectious causes of bronchitis or bronchiolitis|bronchiolar]]-[[Lungs Inflammatory - Pathology#Infectious causes of pneumonia|alveolar]] carcinoma caused by a [[Retroviridae|retrovirus]]
*Commonest under intensive management systems which favour aerosol transmission and close contact of disease
*Behaves like chronic pneumonia
*Takes months to years to express itself clinically as coughing and exercise intolerance
*Gross pathology:
**Heavy lungs which fail to collapse
**The lesions progress from small firm grey/white nodular lesions to extensive confluent areas with replacement by neoplastic tissue
**Cut surface oozes fluid
**There is often coexistent infection present
**Occasional metastases to bronchial and mediastinal lymph nodes can occur
*Histopathology:
**Widespread proliferation of alveolar (Type 2) and terminal bronchiolar epithelium, lining the alveoli and lower airways
**Multiple neoplastic foci of cuboidal/columnar cells forming papillary projections into the lumen
**Metastases of the same in the bronchial and mediastinal lymph nodes
*There is no serological test, and diagnosis depends upon raising the animal by the hind limbs whereupon a clear fluid issues from the nose = "Wheelbarrow test"
*'''[[Jaagsiekte - Pathology|More information]]'''
[[Category:Mammalian Type D retrovirus ]][[Category:Sheep]]
[[Category:Mammalian Type D retrovirus ]][[Category:Sheep]]
[[Category:To_Do_-_Viruses]]
[[Category:To_Do_-_Viruses]]