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| | ==In Pigs== | | ==In Pigs== |
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| − | ===Inclusion body rhinitis===
| + | [[Porcine Cytomegalovirus]] |
| − | [[Image:Inclusion body rhinitis.jpg|right|thumb|100px|<small><center>Inclusion body rhinitis (Image sourced from Bristol Biomed Image Archive with permission)</center></small>]] | |
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| − | *[[Herpesviridae|'''Herpesviridae, porcine cytomegalovirus''']]
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| − | *Disease of suckling piglets 1-5 wks of age
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| − | *Clinical signs: those associated with acute/subacute [[Nasal Cavity Inflammatory - Pathology#Infectious causes of rhinitis|rhinitis]] (ie: serous nasal discharge, progressing to catarrhal or purulent discharge with time and secondary bacterial infections; sneezing; pyrexia), fever in young piglets (3-8wks old)
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| − | *May progress to [[Paranasal Sinuses Inflammatory - Pathology#Sinusitis|sinusitis]], otitis media or [[Lungs Inflammatory - Pathology#Infectious causes of pneumonia|pneumonia]]
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| − | *Morbitity high, mortality low
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| − | *Gross pathology - catarrhal discharge becoming purulent (secondary infection)
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| − | *Histology:
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| − | **Large basophilic [[Degenerations and Infiltrations - Pathology#Cellular Inclusions|intranuclear inclusion bodies]] in the surface and subepithelium of nasal and sinus glandular epithelium with lymphocytic infiltration of the mucosa
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| − | **Bursting of nucleus with cell necrosis and sloughing of necrotic epithelium
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| − | *Can develop viraemic stage, with inclusions and focal necrotising lesions in other organs eg: renal tubular epithelium
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| − | **Usually younger piglets, can die during this phase
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| − | *Usually resolves if uncomplicated but rhinitis may persist if secondary infection is present
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| − | *May persist in pulmonary macrophages
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